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PT-141

$149.00

PT-141 (also known as Bremelanotide) is a synthetic peptide derived from the melanocortin family, originally developed from Melanotan II. Unlike traditional sexual enhancement drugs that target the vascular system, PT-141 works on the central nervous system to stimulate sexual desire and arousal in both men and women. It is FDA-approved for certain female sexual dysfunction indications but is also widely researched off-label for libido enhancement.

Potential Benefits (Based on Existing Research)

PT-141 has been studied for its potential to:

  • Increase sexual desire and arousal in both men and women
  • Support treatment of hypoactive sexual desire disorder (HSDD) in premenopausal women
  • Help with erectile dysfunction in men, especially in cases unresponsive to PDE5 inhibitors
  • Act rapidly without relying on direct blood flow mechanisms
  • Enhance mood and intimacy through melanocortin system stimulation

Note: PT-141 is FDA-approved for specific uses in women. Other applications are investigational and off-label.

Description

Mechanism of Action

PT-141 works by:

  • Binding to melanocortin receptors (MC3R and MC4R) in the brain
  • Stimulating sexual arousal centers in the hypothalamus, unlike PDE5 inhibitors which affect blood vessels
  • Promoting neurogenic arousal, impacting desire and intimacy through the central nervous system

Potential Side Effects / Considerations

  • Nausea (most common side effect, dose-dependent)
  • Flushing, headache, or temporary increase in blood pressure
  • Possible darkening of moles or pigmentation changes (in rare cases)
  • Use with caution in individuals with cardiovascular risk
  • Should not be combined with other melanocortin agonists without clinical guidance

Note: PT-141 is FDA-approved for specific uses in women. Other applications are investigational and off-label.

Additional information

Clinical Information

• Full Name: Bremelanotide (PT-141)
• Sequence: Ac-Nle-cyclo(Asp-His-D-Phe-Arg-Trp-Lys)-OH
(Nle = Norleucine; cyclo = cyclic structure via lactam bridge)
• Molecular Formula: C₅₀H₆₈N₁₄O₁₀
• Molecular Weight: 1025.2 g/mol

Size

30mL

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